2772 Bryant is the left door of a pair, up a small green staircase from the street, leading to another staircase.
Pointless Topology is a 10-15 minute walk from the 24th and Mission BART station. Head east on 24th Street for about half a mile, then turn right on Bryant for two blocks.
Take Caltrain to 22nd Street, then board the 48 bus outbound (to the Sunset District / West Portal) to the 24th and Bryant stop. From there, turn left on Bryant for two blocks.
The 48 stops two blocks north of us on Bryant, and the 27 stops outside our door (Bryant and 26th stop). The westbound terminus of the 33, at Hampshire and 25th, is two blocks northeast of us.
From the Cesar Chavez exit on 101, Bryant and 26th is just a few blocks northwest. Note that street parking may be difficult to find. The nearest parking garage is at SF General Hospital, between 23rd and 24th.
We're usually on Freenode on channel #ptopology.